Movie S1.

Base extrusion path optimized with the PNEB method. TDG is shown in grey; DNA is shown in blue. Arg275 in the interrogation loop and Lys201 in the Pro198 loop are shown in orange. The 5caC base is shown in green. The gating helix is colored in magenta.

Uncovering universal rules governing the selectivity of the archetypal DNA glycosylase TDG

Thomas Dodd, Chunli Yan, Bradley R. Kossmann, Kurt Martin, and Ivaylo Ivanov

PNAS. 2018. 115:5974-5979 DOI: 10.1073/pnas.1803323115