Movie S7.

Video observation of behavioral changes observed after administration of LPS and PAR-1 agonist. Video analysis started immediately after i.v. injection with PAR-1 agonist (6 h post LPS administration). Two subsequent mice were observed in the video; one WT (t = 0 sec) one PodxlΔTie2Cre (t = 58 sec) respectively. Activity was scored by reviewing videos based on total motion observed at 10 s intervals (with 1=normal, 0.5=reduced activity and 0=no activity) and time for full recovery (sustained return to score = 1).