Movie S1.

Molecular dynamics simulation of hNav1.5 channel interaction with lidocaine reveals hydrophilic drug access pathway. Transmembrane view of hNav1.5 channel model (colored in light gray) with sidechains of F1760 and Y1767 shown in stick representation. Lidocaine molecule that accessed the pore lumen through the intracellular gate is shown in spacefilling representation and colored in cyan with nitrogen atoms colored in blue and oxygen atom colored in red. The pore-forming domains I and IV are shown in the front view during the first half of the movie. The pore-forming domains III and IV are shown in the front view during the second half of the movie.