Movie S6.

Calpain-inhibition blocks inflammasome mobilization during pyroptosis. ASC.mCherry expressing THP-1 cells were treated with Ng plus MDL28170 and imaged every 30”for 4 hrs.

Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation

Michael A. Davis, Marian R. Fairgrieve, Andreas Den Hartigh, Olga Yakovenko, Bhargavi Duvvuri, Christian Lood, Wendy E. Thomas, Susan L. Fink, and Michael Gale

PNAS. 2019. 116:5061-5070 DOI: 10.1073/pnas.1818598116

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