Movie S1.

Network evolution during the initial 50 seconds of the simulated association phases for trivalent receptor-ligand interactions in which twisted configurations are either allowed or hindered through alterations to the [Leff] values that drive these binding conformations (see also Fig. 3).

Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

Wesley J. Errington, Bence Bruncsics, and Casim A. Sarkar

PNAS. 2019. 116:25659-25667 DOI: 10.1073/pnas.1902909116