Movie S3.

Illustrating cerebellar behavioral defects in PI31fl/fl Pcp2-cre mice Movie of 7 month-old male PI31fl/fl and PI31fl/fl Pcp2-cre siblings. The PI31fl/fl Pcp2-cre mouse had a halting gait and lost balance frequently, falling back or to the left or right. PI31fl/fl Pcp2-cre mouse has difficulty regaining balance as it falls to the left.

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice

Adi Minis, Jose A. Rodriguez, Avi Levin, Kai Liu, Eve-Ellen Govek, Mary E. Hatten, and Hermann Steller

PNAS. 2019. 116:24639-24650 DOI: 10.1073/pnas.1911921116