Movie S2.

KO Peritoneal macrophage. 3D Reconstruction. Peritoneal macrophages from LysM-Bmal1^-/- (KO), were cultured under control conditions, live cell imaging with ultra-resolution confocal microscopy, using Airyscan detector and F-actin visualisation with SiR-actin.

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

Gareth B. Kitchen, Peter S. Cunningham, Toryn M. Poolman, Mudassar Iqbal, Robert Maidstone, Matthew Baxter, James Bagnall, Nicola Begley, Ben Saer, Tracy Hussell, Laura C. Matthews, David H. Dockrell, Hannah J. Durrington, Julie E. Gibbs, John F. Blaikley, Andrew S. Loudon, and David W. Ray

PNAS. 2020. 117:1543-1551 DOI: 10.1073/pnas.1915932117

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