Movie S2.
B1KO neurons exhibit frequent nuclear membrane ruptures. B1KO neurons expressing NLS-GFP (green) were imaged over 44 h. Repeated transient nuclear membrane ruptures were observed, as judged by the flooding of NLS-GFP into the cytoplasm. Nuclear membrane ruptures were observed in majority of B1KO neurons.
An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death
PNAS. 2019. 116:25870-25879 DOI: 10.1073/pnas.1917225116