Parasternal long axis view from the transthoracic echocardiogram of a 57 year old woman obtained after 3 months of trastuzumab therapy for breast cancer. A mildly reduced left ventricular ejection fraction of 49% is demonstrated. View Video 4 at http://movie-usa.glencoesoftware.com/video/10.1530/ERP-17-0013/video-4.